A randomized trial of endometrial scratching in women with PCOS undergoing ovulation induction cycles.

Author(s): 
Clarke F; East Lancashire NHS Teaching Hospitals Trust
Hammond B; East Lancashire NHS Teaching Hospitals Trust
Milner M; East Lancashire NHS Teaching Hospitals Trust
Shankaralingaiah N; East Lancashire NHS Teaching Hospitals Trust
et al. 
Source: Reproductive biomedicine online, 2022 Feb; Vol. 44 (2), pp. 316-323. 
Abstract: An international, multicentre, randomized, sham-controlled trial across six fertility clinics in three countries (New Zealand, UK and Brazil). Women with a diagnosis of PCOS who were planning to commence ovulation induction cycles (at least three cycles) in order to conceive were randomly assigned to receive the pipelle (scratch) procedure or a sham (placebo) procedure in the first cycle of ovulation induction. No difference was detected in live birth rate for women with PCOS who received an endometrial scratch when trying to conceive using ovulation induction; however, uncertainty remains due to the small sample size in this study. 

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