Author(s) Sur A.; Paria A.
Source European Journal of Pediatrics; 2020
Language English
Publication Date 2020
Despite robust evidence in favour of maintaining optimal oxygen saturation targets in the preterm infants, the titration of oxygen is largely dependent on manual observations and transcription. Similarly, notwithstanding the gaining popularity of non-invasive modalities like high-flow nasal therapy, the practices of weaning and escalating support are largely individualized and based on point of care observations. These are often erroneous and lack objectivity. Histogram analysis from patient monitors is an easy and objective way of quantifying vital parameters and their trends. We review the technology and evidence available behind this practice. .

• Available in full text at European journal of pediatrics from Unpaywall

Author(s) Gray A.; Mackie C.; Price W.; Coupe E.; Holgate S. et al.
Source Pharmacy; Dec 2020; vol. 8 (no. 4); p. 1-19
Language English
Publication Date Dec 2020
The ethos of the pharmacy service at East Lancashire Hospitals NHS Trust (ELHT) could be described as 'let's make things better'. We have a history of innovation involving technology and people; one without the other does not work but together they are synergistic. The Trust currently does not have an electronic patient record (ePR) or electronic prescribing and medicines administration (ePMA), although we do have electronic prescribing for chemotherapy. However, like all Trusts, we have many electronic systems which offer interoperability, or can support making it easier for the pharmacy team to do a good job. This article describes the many fronts we have worked on over the last ten plus years. Taken individually, the elements cannot be considered as revolutionary; together, they have helped us develop and deliver the safe, personal and effective pharmacy service that we call dedicated ward pharmacy.Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

• Available in full text at Pharmacy (Basel, Switzerland) from Unpaywall

Author(s) Byrne E.; Watkinson S.
Source Journal of orthodontics; Nov 2020
Language English
Publication Date Nov 2020
OBJECTIVE: To assess satisfaction of patients and clinicians with virtual appointments using Attend Anywhere for their orthodontic consultation and to identify any areas where the technology could be further utilised. 

Author(s) Garg S.; Chichareon P.; Kogame N.; Takahashi K.; Modolo R. et al.
Source Catheterization and Cardiovascular Interventions; Dec 2020; vol. 96 (no. 7); p. 1369-1378
Language English
Publication Date Dec 2020
Objective: To investigate the impact of different anti-platelet strategies on outcomes after percutaneous coronary intervention (PCI) in patients with established cardiovascular disease (CVD). 

Author(s) Donovan T.; Milan S.J.; Wang R.; Banchoff E.; Bradley P. et al.
Source The Cochrane database of systematic reviews; Dec 2020; vol. 12
Language English
Publication Date Dec 2020
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of hospital admissions, disease-related morbidity and mortality. COPD is a heterogeneous disease with distinct inflammatory phenotypes, including eosinophilia, which may drive acute exacerbations in a subgroup of patients. Monoclonal antibodies targeting interleukin 5 (IL-5) or its receptor (IL-5R) have a role in the care of people with severe eosinophilic asthma, and may similarly provide therapeutic benefit for people with COPD of eosinophilic phenotype. 

• Available in full text at The Cochrane database of systematic reviews from Cochrane Collaboration (Wiley)

Author(s) Hui L.; Shin E.-S.; Jun E.J.; Kim T.-H.; Sohn C.-B.; Choi B.J.; Yuan S.L.; Kun L.; Zhi W.; Hao J.; Zhentao S.; Qiang T.; Bhak Y.; Garg S.
Source Yonsei Medical Journal; Dec 2020; vol. 61 (no. 12); p. 1004-1012
Language English
Publication Date Dec 2020
Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with a high risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections and subsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novo coronary lesions. 

• Available in full text at Yonsei medical journal from EBSCO (MEDLINE Complete)

Author(s) Takahashi K.; Kawashima H.; Ono M.; Hara H.; Wykrzykowska J.J. et al.
Source International Journal of Cardiology; Dec 2020; vol. 320 ; p. 27-34
Language English
Publication Date Dec 2020
Backgrounds: Data on optimal antiplatelet therapy in patients undergoing stenting of the proximal left anterior descending artery (LAD) are limited. Method(s): This is a post-hoc analysis of the GLOBAL LEADERS trial, a prospective, multi-center, randomized controlled trial, comparing the experimental strategy (1-month dual anti-platelet therapy [DAPT] followed by 23-month ticagrelor monotherapy) with the reference regimen (12-month DAPT followed by 12-month aspirin monotherapy) in relation to stenting of the proximal LAD. The primary endpoint was the composite of all-cause death or new Q-wave myocardial infarction (MI) and key secondary safety endpoint was Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding at two years. Result(s): Among 15,845 patients included in the analysis, 3823 (23.9%) patients underwent stenting of the proximal LAD, while 12,022 (75.2%) did not. In the proximal LAD stenting group, there was no significant difference in the risk of the primary endpoint between the two antiplatelet strategies (3.38% vs. 3.93%; hazard ratio [HR]:0.86; 95% CI:0.62-1.20; Pinteraction = 0.951). However, the risk of any MI (2.63% vs. 3.88%; HR:0.68; 95% CI:0.47-0.97; Pinteraction = 0.015) and any revascularization (7.84% vs. 9.94%; HR:0.78; 95% CI:0.63-0.97; Pinteraction = 0.058) was significantly lower in the experimental strategy group, while demonstrating a similar risk of BARC type 3 or 5 bleeding between the two antiplatelet strategies (1.93% vs. 1.99%; HR:0.98; 95% CI:0.62-1.54; Pinteraction = 0.981). Conclusion(s): The present study showed patients having stenting to the proximal LAD could potentially benefit from the experimental strategy with lower ischaemic events without a trade-off in major bleeding at two years.Copyright © 2020 Elsevier B.V.

Author(s) Gao C.; Wang R.; van Geuns R.-J.; Tomaniak M.; Takahashi K. et al.
Source Cardiovascular Diabetology; Dec 2020; vol. 19 (no. 1)
Publication Date Dec 2020
Background: Patients with both diabetes mellitus (DM) and chronic kidney disease (CKD) are a subpopulation characterized by ultrahigh ischemic and bleeding risk after percutaneous coronary intervention. There are limited data on the impact of ticagrelor monotherapy among these patients. 

• Available in full text at Cardiovascular diabetology from EBSCO (MEDLINE Complete)