​Author(s): Al-Mula Abed, Omar W. S.; Srirangam, Shalom J.; Wemyss-Holden, Guy D.
Source: Oman Medical Journal; Sep 2018; vol. 33 (no. 5); p. 374-379
Publication Date: Sep 2018
Publication Type(s): Academic Journal
Available  at Oman Medical Journal -  from Europe PubMed Central - Open Access
Abstract:Objectives: Visible hematuria (VH) is a common urological complaint. A history of initial or terminal VH in men is indicative of a lower urinary tract (LUT) source. A careful clinical history could limit unnecessary extensive upper tract imaging in this group of patients with VH. We conducted a single-center prospective study to examine the usefulness of investigating the upper tract in patients with a history of VH likely from a LUT source (initial and/or terminal VH) with specific reference to the incidence of demonstrable significant upper tract abnormalities. Methods: We conducted a single-center prospective study of consecutive male patients presenting with VH over eight months. All patients underwent standard investigations including physical examination, flexible cystoscopy (FC), and radiological imaging (ultrasound scan (USS) and/or computed tomography urogram (CTU)). Those with a clear history of initial or terminal VH were identified for further scrutiny with regards to detectable upper tracts abnormalities. Results: In total, 57 patients (aged 23--95 years) with initial or terminal VH were identified. Of these, 56 had FC and nine patients were subsequently diagnosed with a LUT malignancy. With regards to upper urinary tract (UUT), 35 patients (61.4%) had an USS, 46 (80.7%) underwent a CTU, and 25 (43.9%) patients had both. In this group, no UUT malignancy was identified on upper tract imaging. Conclusions: Initial or terminal VH patients may not need extensive upper tract imaging. FC is recommended, but a non-invasive USS can be a safe initial investigation for the UUT, with a CTU subsequently considered in those with abnormalities on USS and those with ongoing bleeding. Further combined multicenter analysis will help corroborate these findings and could have several beneficial outcomes including a reduction in investigations cost, patient inconvenience, and ionizing radiation.
Database: CINAHL

​Author(s): Schram C.M.H.
Source: Obstetrician and Gynaecologist; 2018; vol. 20 (no. 2); p. 125-131
Publication Date: 2018
Publication Type(s): Article
Available  at The Obstetrician & Gynaecologist -  from Wiley Online Library Medicine and Nursing Collection 2018 - NHS
Abstract:Key content: Appraisal is a formative and developmental process; annual appraisals are the cornerstones of revalidation. Supporting information for an appraisal should cover the whole scope of work of an obstetrician and gynaecologist, including any educational, managerial or academic work over a 5-year revalidation cycle. The quality of supporting information, including reflection, is more important than the quantity. Supporting information for an appraisal can be found in many day-to-day clinical activities. Learning objectives: To be familiar with the guiding principles of appraisal and revalidation. To appreciate how to provide supporting information that satisfies appraisal and revalidation requirements. To know how to prepare efficiently and effectively for appraisal and revalidation.Copyright © 2018 Royal College of Obstetricians and Gynaecologists
Database: EMBASE

​Author(s): Ryan N.A.J.; Crosbie E.J.; Evans D.G.; Blake D.; Cabrera-Dandy M.; Glaire M.A.
Source: Systematic Reviews; Aug 2018; vol. 7 (no. 1)
Publication Date: Aug 2018
Publication Type(s): Article
Available  at Systematic reviews -  from BioMed Central
Abstract:Background: Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal surveillance, which has been shown to save lives through the detection and removal of premalignant polyps and earlier detection of invasive disease. Endometrial cancer, which is often the sentinel cancer in women, provides an opportunity to diagnose Lynch syndrome and thus enable colorectal surveillance as well as the cascade testing for Lynch syndrome in other family members. These potential benefits have led to a call for the universal screening of women with endometrial cancer for Lynch syndrome, a practice that is now commonplace in colorectal cancer. Healthcare providers and clinicians are however restricted by insufficient knowledge about the prevalence of Lynch syndrome in women with endometrial cancer, with estimates varying as widely as 1-10%. The aim of this study is to perform a systematic review with a meta-analysis of the current literature base in order to estimate the prevalence of Lynch syndrome among women with endometrial cancer to inform this discussion. 
Database: EMBASE

​Author(s): Ahad T.; Riley A.; Martindale E.; von Bremen B.; Owen C.
Source: Pediatric Dermatology; 2018; vol. 35 (no. 1)
Publication Date: 2018
Publication Type(s): Article
PubMedID: 29159956
Available  at Pediatric Dermatology -  from Wiley Online Library Medicine and Nursing Collection 2018 - NHS
Abstract:Vulvar swelling is a rare manifestation of metastatic Crohn's disease in children. It often predates gastrointestinal symptoms and can be the first presentation of pediatric Crohn's disease. We report three cases of pediatric Crohn's disease presenting with vulvar swelling. We discuss this rare presentation and its treatment and highlight the importance of recognizing it so that prompt investigation and appropriate management can be initiated.Copyright © 2017 Wiley Periodicals, Inc.
Database: EMBASE

Author(s): Tian T.M.; Daly B.M.; Owen C.M.
Source: BMJ (Online); 2018; vol. 361
Publication Date: 2018
Publication Type(s): Note
Available  at BMJ   
Database: EMBASE

​Author(s): Her A.-Y.; Kim Y.H.; Shin E.-S.; Garg S.
Source: Coronary Artery Disease; Aug 2018; vol. 29 (no. 5); p. 403-408
Publication Date: Aug 2018
Publication Type(s): Article
Abstract:Objectives Periprocedural myocardial infarction (PMI) is reported to be associated with adverse long-term clinical outcomes. This study compared the rates of PMI following treatment of de novo coronary lesions using either a paclitaxel-coated balloon (PCB) or a newer-generation drug-eluting stent (DES). 

​Author(s): Stewart H.; Abed O.; Wemyss-Holden G.; Srirangam S.
Source: Journal of Clinical Urology; Jun 2018; vol. 11 ; p. 66
Publication Date: Jun 2018
Publication Type(s): Conference Abstract
Abstract:Introduction: We investigated the incidence of upper urinary tract (UUT) abnormalities in males with initial and/or terminal visible haematuria (VH) suggesting a lower urinary tract (LUT) cause. Is extensive UUT imaging really necessary? Materials/Method: Two-armed (retrospective (n=419) and prospective (n=1173)) study of all consecutive male patients with VH over 5 years. All patients underwent flex-ible cystoscopy (FC) and UUT imaging (USS+/-IVU/CT urogram). Those with initial and/or terminal VH were scrutinised further. Results: 62/419 (14.8%) of patients in the retrospective group (R-G) and 183/1173 (15.6%) in the prospective group (P-G) presented with initial and/or terminal VH. In the R-G, FC revealed these LUT abnormalities: 4 bladder calculi; 3 bladder tumours; 1 urethral stricture. Only one UUT malignancy was identified (single case of renal cell carcinoma detected on USS and IVU). 

​Author(s): Hosny K.; Luk A.
Source: Annals of the Royal College of Surgeons of England; Jul 2018; vol. 100 (no. 6)
Publication Date: Jul 2018
Publication Type(s): Article
PubMedID: 29962297
Available  at Annals of the Royal College of Surgeons of England -  from EBSCO (MEDLINE Complete)
Abstract:Schistosoma haematobium is the species primarily responsible for the manifestation of schistosomiasis in the genitourinary tract. It is a parasitic disease caused by flukes (trematodes) of the genus Schistosoma, which can result in acute and chronic manifestation. We report a case of urinary schistosomiasis that initially presented as advanced bladder cancer with pulmonary metastasis on initial computed tomography scan. 

​Author(s): Ismail D.; Owen C.M.
Source: British Journal of Dermatology; Jul 2018; vol. 179 ; p. 159-160
Publication Date: Jul 2018
Publication Type(s): Conference Abstract
Abstract:Lichen sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the anogenital region in prepubertal girls and postmenopausal women. The underlying cause is not fully known, although many aetiological factors have been implicated. It has an estimated prevalence of 1 in 900 girls (Powell J, Wojnarowska F. Childhood lichen sclerosus: an increasingly common problem. J Am Acad Dermatol 2001; 44: 803-6) and typical clinical features include white atrophic plaques, erosions, fissures and ecchymoses in the anogenital region. 

​Author(s): Waqar-Uddin H.; Wilson J.; Habgood M.
Source: Anaesthesia; Jul 2018; vol. 73 ; p. 121
Publication Date: Jul 2018
Publication Type(s): Conference Abstract
Abstract:Around 160,000 hip and knee replacements are performed every year in the UK [1]. Numerous studies across surgical specialties have shown that pre-operative anaemia is associated with longer length of stay (LoS) in hospital and higher mortality [2]. It has been recommended that patients who present for elective surgery and are found to be anaemic pre-operatively, their operation should be postponed until the anaemia has been investigated and treated adequately. A cut-off of 130 g.l-1 has been suggested [3]. At the same time, the UK Blood Transfusion service has introduced the 'two sample rule' so patients who require transfusion need two blood samples. Our aim was to assess whether our service was functioning well in identifying patients with anaemia and optimising them prior to surgery. 

​Author(s): Choudry Q.A.; Paton R.W.
Source: Bone and Joint Journal; Jun 2018 (no. 6); p. 806-810
Publication Date: Jun 2018
Publication Type(s): Article
PubMedID: 29855244
Abstract:Aims The aim of this prospective cohort study was to evaluate the effectiveness of the neonatal hip instability screening programme. Patients and Methods The study involved a four-year observational assessment of a neonatal hip screening programme. All newborns were examined using the Barlow or Ortolani manoeuvre within 72 hours of birth; those with positive findings were referred to a 'one-stop' screening clinic for clinical and sonographic assessment of the hip. The results were compared with previous published studies from this unit. Results A total of 124 newborns with a positive Barlow or Ortolani manoeuvre, clunk positive, or 'unstable' were referred. 

​Author(s): Johnson, Sarah
Source: MIDIRS Midwifery Digest; Jun 2018; vol. 28 (no. 2); p. 176-183
Publication Date: Jun 2018
Publication Type(s): Academic Journal
Database: CINAHL

​Author(s): Johnston B.; Ahmed T.; Al-Moasseb Z.; Habgood M.; Clarke S.; Krige A.
Source: Journal of the Intensive Care Society; May 2018; vol. 19 (no. 2); p. 9-10
Publication Date: May 2018
Publication Type(s): Conference Abstract
Abstract:Introduction: Enteral nutrition and adequate calorie intake has been associated with reduced infections and improved survival in critically ill patients. Despite this evidence data suggests patients do not achieve their daily calorific requirement. This 'iatrogenic underfeeding' is thought to be widespread with the CALORIES study revealing that only 10%-30% of prescribed daily kCal was delivered to patients. 

​Author(s): FAROUG, RAD; AHMED, ABDULKHALED; ALI, CHADI; WHITTAKER, MEGAN
Source: Synergy: Imaging & Therapy Practice; May 2018 ; p. 26-28
Publication Date: May 2018
Publication Type(s): Periodical
Database: CINAHL

​Author(s): Chukkambotla S.
Source: Journal of the Intensive Care Society; May 2018; vol. 19 (no. 2); p. 26
Publication Date: May 2018
Publication Type(s): Conference Abstract
Abstract:Background: Patients with Interstitial Lung Disease presented with acute respiratory failure often referred to intensive care for ventilatory support. The study objective is to report the clinical outcomes of patients who have been admitted to intensive care unit with known or unknown Interstitial Lung Disease. 

​Author(s): Tomlinson, Robert
Source: Journal of perioperative practice; May 2018; vol. 28 (no. 5); p. 115-119
Publication Date: May 2018
Publication Type(s): Journal Article
PubMedID: 29734935
Abstract:Reacting to a never event is difficult and often embarrassing for staff involved. East Lancashire Hospitals NHS Trust has demonstrated that treating staff with respect after a never event, creates an open culture that encourages problem solving and service improvement. The approach has allowed learning to be shared and paved the way for the trust to be the first in the UK to launch the patient centric behavioural noise reduction strategy 'Below ten thousand'.

​Author(s): Lucente, Ermelinda; Liu, Hongguang; Liu, Yang; Hu, Xiang; Lacivita, Enza; Leopoldo, Marcello; Cheng, Zhen
Source: Bioconjugate chemistry; May 2018; vol. 29 (no. 5); p. 1595-1604
Publication Date: May 2018
Publication Type(s): Journal Article
PubMedID: 29587479
Abstract:Bombesin receptor 2 (BB2) and integrin αvβ3 receptor are privileged targets for molecular imaging of cancer because of their overexpression in a number of tumor tissues. The most recent developments in heterodimer-based radiopharmaceuticals concern BB2- and integrin αvβ3-targeting compounds, consisting of bombesin (BBN) and cyclic arginine-glycine-aspartic acid peptides (RGD), connected through short length linkers. 

​Author(s): El Muntasar A.; Toner E.; Alkhazaaleh O.A.; Arumugam D.; Shah N.; Hajibandah S.; Hajibandeh S.
Source: World Journal of Emergency Medicine; 2018; vol. 9 (no. 2); p. 85-92
Publication Date: 2018
Publication Type(s): Review
Available  at World Journal of Emergency Medicine -  from Europe PubMed Central - Open Access
Abstract:BACKGROUND: The management of complex pattern of bleeding associated with pelvic trauma remains a big challenge for trauma surgeons. We aimed to conduct a comprehensive meta-analysis to compare the outcomes of angioembolisation and pelvic packing in patients with pelvic trauma. METHODS: We conducted a systematic search of electronic information sources, including MEDLINE; EMBASE; CINAHL; the CENTRAL; the World Health Organization International Clinical Trials Registry; ClinicalTrials.gov; ISRCTN Register, and bibliographic reference lists. The primary outcome was defined as mortality. Combined overall effect sizes were calculated using randomeffects models. Results are reported as the odds ratio (OR) and 95% confi dence interval (CI). RESULTS: We identified 3 observational studies reporting a total of 120 patients undergoing angioembolisation (n=60) or pelvic packing (n=60) for pelvic trauma. Reporting of the Injury Severity Score (ISS) was variable, with higher ISS in the pelvic packing group. The risk of bias was low in two studies, and moderate in one. The pooled analysis demonstrated that angioembolisation did not signifi cantly reduce mortality in patients with pelvic trauma compared to surgery (OR=1.99; 95% CI= 0.83-4.78, P=0.12). There was mild between-study heterogeneity (I2=0%, P=0.65). CONCLUSION: Our analysis found no signi f icant di fference in mortal i ty between angioembolisation and pelvic packing in patients with traumatic pelvic haemorrhage. The current level of evidence in this context is very limited and insuffi cient to support the superiority of a treatment modality. Future research is required.Copyright © 2017 World Journal of Emergency Medicine.
Database: EMBASE

​Author(s): Her A.-Y.; Shin E.-S.; Lee J.M.; Garg S.; Doh J.-H.; Nam C.-W.; Koo B.-K.
Source: International Journal of Cardiovascular Imaging; Apr 2018 ; p. 1-9
Publication Date: Apr 2018
Publication Type(s): Article In Press
Abstract:There is limited data on the efficacy of paclitaxel-coated balloon (PCB) compared to stents for de novo coronary lesions. The purpose of this study was to compare the efficacy of PCB treatment with stent implantation for de novo coronary lesions after successful plain old balloon angioplasty (POBA) guided by fractional flow reserve (FFR). In 200 patients scheduled for elective percutaneous coronary intervention (PCI) for de novo lesions, FFR was measured after POBA (POBA-FFR). If POBA-FFR was >= 0.75, patients were treated with PCB (PCB group, n = 78) or stent (Stent group, n = 73). If POBA-FFR was < 0.75, stent was implanted as planned (Reference group, n = 42). The primary endpoint was late lumen loss at 9 months and the secondary endpoint was adverse cardiac events (cardiac death, myocardial infarction, target lesion thrombosis, or repeat revascularization) at 12 months follow-up. There was no between-group differences in the POBA-FFR (0.87 +/- 0.05 in PCB, 0.89 +/- 0.06 in stent, p = 0.101). At 9 months, late lumen loss was significantly lower in the PCB group compared to the Stent group (0.05 +/- 0.33 vs. 0.59 +/- 0.76 mm, p < 0.001). Adverse cardiac events were not different between the PCB, Stent and Reference groups (2.6, 5.5, and 9.5% respectively; p = 0.430 for PCB vs. Stent group; p = 0.229 for the reference vs. both other groups). PCB treatment guided by POBA-FFR showed excellent 9 months angiographic and functional results, as well as comparable 12 months clinical outcomes, compared with stent implantation for de novo coronary lesions.Copyright © 2018 Springer Science+Business Media B.V., part of Springer Nature
Database: EMBASE

​Author(s): Abdulla, Omar; Ahmad, Sarfraz
Source: British Journal of Hospital Medicine (17508460); May 2018; vol. 79 (no. 5); p. 294-294
Publication Date: May 2018
Publication Type(s): Academic Journal
Available  at British Journal of Hospital Medicine -  from MAG Online Library
Abstract:The article presents a case study of a 60-year-old man with abdominal pain and distention which was diagnosed as the rare azygos vein thrombosis which in turn helped to prevent the development of pulmonary embolism.
Database: CINAHL

​Author(s): Tomlinson, Robert
Source: Journal of perioperative practice; May 2018; vol. 28 (no. 5); p. 115-119
Publication Date: May 2018
Publication Type(s): Journal Article
PubMedID: 29734935
Abstract:Reacting to a never event is difficult and often embarrassing for staff involved. East Lancashire Hospitals NHS Trust has demonstrated that treating staff with respect after a never event, creates an open culture that encourages problem solving and service improvement. The approach has allowed learning to be shared and paved the way for the trust to be the first in the UK to launch the patient centric behavioural noise reduction strategy 'Below ten thousand'.
Database: Medline

Author(s): Campbell R.; Nelson E.; Hocking J.; Hickey T.; Hodgins J.; Geraghty V.
Source: Journal of Crohn's and Colitis; Feb 2018; vol. 12
Publication Date: Feb 2018
Publication Type(s): Conference Abstract
Abstract:Background: In the current financial climate the NHS is under pressure to change medications in order to improve the cost-effectiveness of prescribing. Despite this practice being widespread, there is a paucity of information on how patients feel about these changes. A key strategy for preventing relapses in patients with inflammatory bowel disease (IBD) is treatment with Mesalazine. Anecdotal reports have suggested that IBD patients find changes in their IBD medication worrying and that this may destabilise symptom control. 
Database: EMBASE

​Author(s): Doherty C.; Bowler M.; Sadadcharam M.; Perkins R.; Bateman N.; Bruce I.A.; Monks S.; English C.; Atkinson D.; McGrath B.
Source: Clinical Otolaryngology; Apr 2018; vol. 43 (no. 2); p. 674-678
Publication Date: Apr 2018
Publication Type(s): Letter
Available  at Clinical Otolaryngology -  from Wiley Online Library Medicine and Nursing Collection 2018 - NHS
Database: EMBASE

Author(s): Patel L.B.; Stuart-Booth S.; Rakshi K.
Source: Archives of Disease in Childhood; Mar 2018; vol. 103
Publication Date: Mar 2018
Publication Type(s): Conference Abstract
Available  at Archives of Disease in Childhood -  from BMJ Journals - NHS
Abstract:Aims The incidence of autism in the UK is predicted at 0.1%; 1 00 000 children and 7 00 000 adults. Diagnosis of Autism Spectrum Disorder (ASD) varies regionally though national standards are outlined; NICE Clinical guideline (CG128) and Quality standard (QS51). 
Database: EMBASE

Author(s): Hajibandeh, S.; Deering, R.; McEleney, D.; Guirguis, J.; Dix, S.; Sreh, A.; Toner, E.; El Muntasar, A.; Kausar, A.; Sheikh, G.; OShea, D.; Shafiq, A.; Kelly, A.; Khan, A.; Arumugam, D.; Evan, A.; Evans, A
Source: Hernia; Apr 2018; vol. 22 (no. 2); p. 243-248
Publication Date: Apr 2018
Publication Type(s): Academic Journal
PubMedID: 29243213
Available  at Hernia -  from EBSCO (MEDLINE Complete)
Abstract:Objectives: To determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of routinely collected co-morbidity data in patients undergoing abdominal wall hernia repair.
Database: CINAHL