Author(s) Wong ; Viyasar, Thevarajah; Layton, Benjamin; Lauder, Joshua
Source British Journal of Hospital Medicine (17508460); Nov 2022; vol. 82 (no. 11); p. 369-376
Language English
Publication Date Nov 2022
DOI 10.12968/hmed.2021.0322
ISSN 17508460
Database CINAHL
Nitrous oxide, also known as 'laughing gas', is one of the most widely used recreational drugs among teenagers in the UK. Copious inhalation of nitrous oxide may increase intra-alveolar pressure, resulting in barotrauma secondary to alveolar rupture. Pneumomediastinum and subcutaneous emphysema are common clinical findings in nitrous oxide-associated barotrauma. Prolonged nitrous oxide misuse may inactivate vitamin B12 through the alteration of its metabolism, causing demyelination of the central and peripheral nervous system. A spectrum of neurological manifestations has been reported, including peripheral neuropathy, myelopathy and subacute combined degeneration of the spinal cord. Medical therapies and psychosocial interventions aiming at nitrous oxide cessation are important treatment steps to achieve partial or complete recovery from the adverse effects associated with inhalation of nitrous oxide.

• Available in full text at British journal of hospital medicine (London, England : 2005) from MAG Online Library

Author(s) Conti I.; Cross B.; Rooney A.G.; Nicholson T.R.
Source Journal of the Neurological Sciences; Jul 2021; vol. 426
Database EMBASE

• Available in full text at Journal of the neurological sciences from Unpaywall