Source: Bioconjugate chemistry; May 2018; vol. 29 (no. 5); p. 1595-1604
Publication Date: May 2018
Publication Type(s): Journal Article
Abstract:Bombesin receptor 2 (BB2) and integrin αvβ3 receptor are privileged targets for molecular imaging of cancer because of their overexpression in a number of tumor tissues. The most recent developments in heterodimer-based radiopharmaceuticals concern BB2- and integrin αvβ3-targeting compounds, consisting of bombesin (BBN) and cyclic arginine-glycine-aspartic acid peptides (RGD), connected through short length linkers.