Author(s): McCarthy E.M.; Parker B.; Bruce I.N.; Sutton E.; Nesbit S.; Jayne D.; Griffiths B.; Isenberg D.A.; Rahman A.; Gordon C.; D'Cruz D.P.; Rhodes B.; Lanyon P.; Vital E.M.; Yee C.-S.; Edwards C.J.; Teh L.-S.; Akil M.; McHugh N.J.; Zoma A.

Source: Rheumatology (United Kingdom); Jun 2017; vol. 56 (no. 6); p. 1049

Publication Date: Jun 2017

Publication Type(s): Erratum

Abstract:The title of the above paper has been adapted after publication ahead of print. The original title of The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence has been adapted to The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales.Copyright © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
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Database: EMBASE

​Author(s): McCarthy E.M.; Parker B.; Bruce I.N.; Sutton E.; Nesbit S.; Jayne D.; Griffiths B.; Isenberg D.A.; Rahman A.; Gordon C.; D'Cruz D.P.; Rhodes B.; Lanyon P.; Vital E.M.; Yee C.-S.; Edwards C.J.; Teh L.-S.; Akil M.; McHugh N.J.; Zoma A.

Source: Rheumatology (United Kingdom); Jun 2017; vol. 56 (no. 6); p. 1041-1043

Publication Date: Jun 2017

Publication Type(s): Letter
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Database: EMBASE

Source: Arthritis Care and Research; Oct 2016; vol. 68 (no. 10); p. 1505-1513

Publication Type(s): Journal: Article

Author(s): McElhone K.; Teh L.-S.; Abbott J.; Sutton C.; Mullen M.; Lanyon P.; Rahman A.; Yee C.-S.; Akil M.; Bruce I.N.; Ahmad Y.; Gordon C.

Abstract:Objective: As a health-related quality of life (HRQOL) measure, the LupusQoL is a reliable and valid measure for adults with systemic lupus erythematosus (SLE). This study evaluates the responsiveness and minimal important differences (MIDs) for the 8 LupusQoL domains. Methods: Patients experiencing a flare were recruited from 9 UK centers. At each of the 10 monthly visits, HRQOL (LupusQoL, Short Form 36 health survey [SF-36]), global rating of change (GRC), and disease activity using the British Isles Lupus Assessment Group 2004 index were assessed.

The responsiveness of the LupusQoL and the SF-36 was evaluated primarily when patients reported an improvement or deterioration on the GRC scale and additionally with changes in physician-reported disease activity. MIDs were estimated as mean changes when minimal change was reported on the GRC scale. Results: A total of 101 patients were recruited. For all LupusQoL domains, mean HRQOL worsened when patients reported deterioration and improved when patients reported an improvement in GRC; SF-36 domains showed comparable responsiveness.

​Improvement in some domains of the LupusQoL/SF-36 was observed with a decrease in disease activity, but when disease activity worsened, there was no significant change. LupusQoL MID estimates for deterioration ranged from -2.4 to -8.7, and for improvement from 3.5 to 7.3; for the SF-36, the same MID estimates were -2.0 to -11.1 and 2.8 to 10.9, respectively. Conclusion: All LupusQoL domains are sensitive to change with patient-reported deterioration or improvement in health status. For disease activity, some LupusQoL domains showed responsiveness when there was improvement but none for deterioration. LupusQoL items were derived from SLE patients and provide the advantage of disease-specific domains, important to the patients, not captured by the SF-36. 

​Source: Arthritis care & research; Oct 2016; vol. 68 (no. 10); p. 1505-1513

Publication Type(s): Journal Article

Author(s): McElhone, Kathleen; Abbott, Janice; Sutton, Chris; Mullen, Montana; Lanyon, Peter; Rahman, Anisur; Yee, Chee-Seng; Akil, Mohammed; Bruce, Ian N; Ahmad, Yasmeen; Gordon, Caroline; Teh, Lee-Suan

Abstract:As a health-related quality of life (HRQOL) measure, the LupusQoL is a reliable and valid measure for adults with systemic lupus erythematosus (SLE). This study evaluates the responsiveness and minimal important differences (MIDs) for the 8 LupusQoL domains.        

Patients experiencing a flare were recruited from 9 UK centers. At each of the 10 monthly visits, HRQOL (LupusQoL, Short Form 36 health survey [SF-36]), global rating of change (GRC), and disease activity using the British Isles Lupus Assessment Group 2004 index were assessed. The responsiveness of the LupusQoL and the SF-36 was evaluated primarily when patients reported an improvement or deterioration on the GRC scale and additionally with changes in physician-reported disease activity. MIDs were estimated as mean changes when minimal change was reported on the GRC scale.        

A total of 101 patients were recruited. For all LupusQoL domains, mean HRQOL worsened when patients reported deterioration and improved when patients reported an improvement in GRC; SF-36 domains showed comparable responsiveness. Improvement in some domains of the LupusQoL/SF-36 was observed with a decrease in disease activity, but when disease activity worsened, there was no significant change. LupusQoL MID estimates for deterioration ranged from -2.4 to -8.7, and for improvement from 3.5 to 7.3; for the SF-36, the same MID estimates were -2.0 to -11.1 and 2.8 to 10.9, respectively. All LupusQoL domains are sensitive to change with patient-reported deterioration or improvement in health status. For disease activity, some LupusQoL domains showed responsiveness when there was improvement but none for deterioration. LupusQoL items were derived from SLE patients and provide the advantage of disease-specific domains, important to the patients, not captured by the SF-36.         

Citation: Musculoskeletal care, Jun 2016, vol. 14, no. 2, p. 110-115, 1557-0681 (June 2016)
 
Author(s): Williams, Anita Ellen, Cherry, Lindsey, Blake, Alison, Alcacer-Pitarch, Begonya, Edwards, Christopher, Hopkinson, Neil, Vital, Edward, Teh, Lee-Suan
 
Abstract: Systemic lupus erythematosus (SLE) can manifest with arthralgia and myalgia, and, in severe cases, disorganization of the joints and tendon rupture. Further, Raynaud's phenomenon and other circulatory problems such as vasculitis have been reported, and may be associated with loss of sensation and ulcers. Associated with impaired peripheral neurovascular function there is the potential for changes in tissue viability leading to thinning of the skin or callus formation. In addition, resistance to infections may be reduced, such as fungal infection of the skin and nails, bacterial infection associated with wounds and viral infections such as verruca. There is a dearth of evidence for the effects of SLE in the foot, the prevalence of foot problems in SLE and the impact of these on the individual. In addition, it is not known if people with SLE and foot problems have access to specialist care through foot health services. Hence, there is a need to investigate the scale of foot problems associated with SLE. In order to achieve this, a questionnaire needs to be developed in order to carry out a national survey in England. The items required for the questionnaire were generated using a focus group, which comprised patient advisers with SLE, consultants who specialized in SLE, specialist rheumatology podiatrists and specialist rheumatology nurses. From this consensus approach to the item generation, the draft questionnaire was developed with agreement on themes, question format and overall structure. Additionally, the Manchester Pain and Disability Questionnaire was included in order to capture levels of pain and associated disability. An iterative process followed, with feedback from the focus group reducing the number of other items from 53, until the penultimate version of questionnaire was produced with 50 items. Following on from this, a process of cognitive debriefing was used with two people with SLE who were naïve to the questionnaire. Minor changes to two questions and the layout was required before a final version of the questionnaire was produced. The questionnaire will be used for a study which aims to identify the frequency of patients' self-reported foot problems, the impact of foot problems on their lives and the status of foot care provision. This will be achieved through a survey of people with SLE across six clinical sites and interviews with some people in order to explore their experience of foot problems. The results from the present study will provide the information required to inform further research. In addition, it could potentially inform the design and delivery of foot health information and services to this patient group. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.
 
Source: Medline
 
Full Text:
Available from John Wiley and Sons in Musculoskeletal Care
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​Citation: Rheumatology (United Kingdom), May 2016, vol./is. 55/5(953-954), 1462-0324;1462-0332 (01 May 2016)
 
Author(s): Lazarewicz K., Brockbank J., Chinoy H.
 
Language: English
 
Publication Type: Journal: Letter
 
Source: EMBASE

Citation: Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation, Jul 2015, vol. 24, no. 7, p. 1749-1758, 0962-9343 (Jul 2015)

Author(s): Meacock, Rachel, Harrison, Mark, McElhone, Kathleen, Abbott, Janice, Haque, Sahena, Bruce, Ian, Teh, Lee-Suan

Abstract: Purpose: To derive a mapping algorithm to predict SF-6D utility scores from the non-preference-based LupusQoL and test the performance of the developed algorithm on a separate independent validation data set. Method: LupusQoL and SF-6D data were collected from 320 patients with systemic lupus erythematosus (SLE) attending routine rheumatology outpatient appointments at seven centres in the UK. Ordinary least squares (OLS) regression was used to estimate models of increasing complexity in order to predict individuals’ SF-6D utility scores from their responses to the LupusQoL questionnaire. Model performance was judged on predictive ability through the size and pattern of prediction errors generated. The performance of the selected model was externally validated on an independent data set containing 113 female SLE patients who had again completed both the LupusQoL and SF-36 questionnaires. Results: Four of the eight LupusQoL domains (physical health, pain, emotional health, and fatigue) were selected as dependent variables in the final model. Overall model fit was good, with R2 0.7219, MAE 0.0557, and RMSE 0.0706 when applied to the estimation data set, and R2 0.7431, MAE 0.0528, and RMSE 0.0663 when applied to the validation sample. Conclusion: This study provides a method by which health state utility values can be estimated from patient responses to the non-preference-based LupusQoL, generalisable beyond the data set upon which it was estimated. Despite concerns over the use of OLS to develop mapping algorithms, we find this method to be suitable in this case due to the normality of the SF-6D data. (PsycINFO Database Record (c) 2015 APA, all rights reserved)(journal abstract)

Source: PsycInfo

Citation: British Journal of General Practice, May 2015, vol./is. 65/634(266-267), 0960-1643 (01 May 2015)

Author(s): Carney R., Buhary T., Teh L.-S., Gayed S.

Publication Type: Journal: Article

Source: EMBASE

Full Text:

Available from EBSCOhost in British Journal of General Practice