Invasive versus medically managed acute coronary syndromes with prior bypass (CABG-ACS): Insights into the registry versus randomised trial populations

Author(s) Lee M.M.Y.; Petrie M.C.; Simpson J.; Jackson C.E.; Corcoran D.S. et al.
Source Open Heart; Feb 2021; vol. 8 (no. 1)
Background Coronary artery bypass graft (CABG) patients are under-represented in acute coronary syndrome (ACS) trials. We compared characteristics and outcomes for patients who did and did not participate in a randomised trial of invasive versus non-invasive management (CABG-ACS). Methods ACS patients with prior CABG in four hospitals were randomised to invasive or non-invasive management. Non-randomised patients entered a registry. Primary efficacy (composite of all-cause mortality, rehospitalisation for refractory ischaemia/angina, myocardial infarction (MI), heart failure) and safety outcomes (composite of bleeding, stroke, procedure-related MI, worsening renal function) were independently adjudicated. 

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