ELHT Evidence Hub
  • Home
  • Meet the Team
  • Library Facilities
  • Education, Research and Innovation
Picture

Paediatric vulval lichen sclerosus: a retrospective study

25/10/2019

0 Comments

 
Author(s) Ismail D.; Owen C.M.
Source Clinical and Experimental Dermatology; Oct 2019; vol. 44 (no. 7); p. 753-758
Publication Date Oct 2019
DOI 10.1111/ced.13894
Background: Lichen sclerosus (LS) is a chronic inflammatory dermatosis with a predilection for the anogenital region, which mainly affects prepubertal girls and postmenopausal women. The cause is unknown, but a number of potential aetiological factors have been identified.

Aim(s): To examine a cohort of patients with prepubertal-onset vulval LS (VLS) and assess baseline characteristics, clinical presentation, potential precipitating and predisposing factors, and response to treatment. Method(s): Data were collected from case notes on patients aged < 18 years diagnosed with prepubertal-onset VLS attending a specialist vulval dermatology service. Data included clinical presentation, comorbidities, family history, therapy and response to treatment.

Result(s): In total, 26 paediatric patients were identified. The median age at onset of symptoms was 5 years (range 2-8.5 years). Many previously identified potential aetiological factors for the development of VLS were identified, including family history, trauma, autoimmune disease and hormonal factors. A significant proportion of patients had a history of urinary tract symptoms, including incontinence and urinary tract infection. Most patients responded well to a standard course of induction topical therapy followed by maintenance therapy, but some, including three patients with ongoing urinary incontinence and three postpubertal patients, continued to have active disease.

​Conclusion(s): A detailed assessment is essential in patients with VLS so that potential predisposing factors and comorbidities can be identified and managed. Urinary incontinence may be implicated in the development of paediatric VLS and may prevent adequate disease control. Paediatric VLS can persist through puberty, thus long-term follow-up is advised.Copyright © 2019 British Association of Dermatologists
  • Available in full text at Clinical and experimental dermatology from Wiley Online Library Medicine and Nursing Collection 2019 - NHS
0 Comments



Leave a Reply.

    The following databases were searched:
    EMBASE,  MEDLINE, PsycINFO, BNI, CINAHL, 
    to find  ELHT staff publications

    Specialties

    All
    ANAESTHETICS
    CARDIOLOGY
    COVID 19
    DERMATOLOGY
    DIABETES
    DIETETICS
    EMERGENCY CARE
    GYNAECOLOGY
    MAXILLOFACIAL
    NEONATOLOGY
    OBSTETRICS
    ONCOLOGY
    ORTHOPAEDICS
    PAEDIATRICS
    PAIN
    PHARMACY
    RADIOLOGY
    RESPIRATORY
    SURGERY
    UROLOGY
    VASCULAR SURGERY

    RSS Feed

    Archives - past 2 years

    December 2020
    November 2020
    October 2020
    September 2020
    July 2020
    June 2020
    May 2020
    April 2020
    March 2020
    February 2020
    January 2020
    December 2019
    November 2019
    October 2019
    September 2019
    August 2019
    January 2019
    December 2018

Learning Centre Library
Royal Blackburn Teaching Hospital
library.blackburn@elht.nhs.uk
01254 734312 or Ext 84312

​Find us

Staffed Opening Hours
Mon      08:30-16:30
Tue       08:30-16:30
Wed     08:30-16:30
Thu      08:30-16:30
Fri         08:30-16:00
Mackenzie Library
Burnley General Teaching Hospital
library.burnley@elht.nhs.uk
01282 803114 or Ext. 13114

Find us

Staffed Opening Hours
Mon      08:30-16:00
Tue       08:30-16:00
Wed     08:30-16:00
Thu       08:30-16:00
Fri         Unstaffed

FAQS
​Library Catalogue
Library @lerts
​Your Specialty or Professional Group
Membership Terms & Conditions
Privacy Policy
Our Performance
​Your Feedback
​Specialty Journals

Picture
Picture
24/7 access to the library is available - please see library staff
Picture
  • Home
  • Meet the Team
  • Library Facilities
  • Education, Research and Innovation